The Complete Science Behind Avtriee

Every claim, every benefit, every ingredient — backed by decades of published peer-reviewed research. This is the full picture.

30+

Human Clinical Studies

20+

Years Research

6

Health Categories

— Ingredient Deep Dive

What Powers Every Softgel

There is a reason Avtriee® feels different from other Vitamin E supplements. It starts with T3E™, a natural Vitamin E tocotrienol ingredient derived from Malaysian palm oil.

One of the most researched forms of Vitamin E, studied across brain health, liver function, heart health, and inflammation for over 30 years.

Most people have been taking Vitamin E for years without knowing there is a more complete form. T3E™ is that form — the one that gives your body the full picture, not just part of it.

Where it comes from matters too.

Every T3E™ tocotrienol in Avtriee® is grown and processed by Sarawak Oil Palms — a Bursa Malaysia listed company that owns the plantations, runs the milling, and controls the entire process from start to finish.

You know where it comes from. You know how it is made. There is nothing in between.

That is what powers every Avtriee® softgel. A complete ingredient. A traceable source. Thirty years of science behind every capsule you take.

— Structural Science —

The Science Behind Tocotrienols.

And Why It Matters For Your Health.

Tocotrienols have been safely used as a health supplement for over 20 years worldwide. Today, there are more than 20 completed clinical studies and more than 10 ongoing clinical trials studying tocotrienols across various health conditions globally.

What Makes Tocotrienols Structurally Different

Tocotrienols are part of the Vitamin E family — structurally similar to tocopherols, with one key difference.

Instead of a saturated phytyl tail, tocotrienols have an unsaturated side chain. This structural difference is what makes tocotrienols a stronger antioxidant than tocopherols.

Tocotrienols act as a chain-breaking antioxidant, preventing the oxidation of fats inside your body and scavenging harmful free radicals before they cause damage.

Their unsaturated side chain allows them to penetrate cell membranes more effectively than other types of antioxidants, reaching the place where free radical damage actually begins.

— What Researchers Found —

🧠 On Brain Health

A clinical study published in the renowned journal, Stroke, reported that tocotrienols showed neuroprotective effects by slowing down the progression of brain white matter lesions in human subjects. A separate study shown that alpha-tocotrienol as the most potent neuroprotective form of natural Vitamin E.

🫁 On Liver Health

A randomised placebo-controlled clinical trial published in Nutrition Journal — led by Emeritus Professor Dr Yuen Kah Hay — reported that tocotrienols supported the reduction of liver fat in patients with fatty liver. A 2023 systematic review published in Nutrients reviewed tocotrienols as a promising management strategy for NAFLD.

❤️ On Heart Health

Research published in Atherosclerosis found that tocotrienols may modulate key cholesterol transporters and genes involved in atherosclerosis. A study published in the Journal of Biological Chemistry found that tocotrienols regulate cholesterol production at the cellular level. ¹

🔥 On Inflammation

Research published in Food Research International found that palm oil tocotrienols exhibit anti-inflammatory and antioxidant characteristics comparable to or exceeding those of tocopherols.

✨ On Skin Health

A study published in the Journal of Cosmetic Dermatology found that tocotrienols protect the skin against UV-induced inflammation. A 2022 systematic review published in Frontiers in Pharmacology reviewed the role of tocotrienols in supporting skin health as it undergoes changes due to aging.

Is It Natural?

The tocotrienols in Avtriee® are sustainably extracted by Sarawak Oil Palms Berhad — ensuring the ingredient is responsibly sourced at every step.

¹ Parker RA, Pearce BC, Clark RW, Gordon DA, Wright JJ. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Journal of Biological Chemistry. May 1993. https://pubmed.ncbi.nlm.nih.gov/8486659/

The Research Collaborations

Behind Avtriee

The science behind Avtriee® was not developed alone. It was built through years of working closely with some of Malaysia's most respected research and clinical institutions.

Universiti Sains Malaysia (USM)

This is where it all started. Emeritus Professor Dr Yuen Kah Hay spent decades at USM studying Malaysian palm tocotrienols, how they work in the body, how they are absorbed, and how they can support human health.

Everything Avtriee® is built on traces back to this research.

Monash University Malaysia

AvantHealth's collaboration with Monash University Malaysia focuses on education and awareness, advancing the understanding of tocotrienols and their role in supporting human health.

Sarawak General Hospital

Research done with Sarawak General Hospital takes the science out of the lab and into real clinical settings — studying tocotrienols in actual patients, under proper hospital conditions.

CRC Sarawak General Hospital

The CRC Sarawak General Hospital supports the clinical study of tocotrienols, contributing to the growing body of human evidence on tocotrienol research.

Malaysian Palm Oil Board (MPOB)

The tocotrienols in Avtriee are sustainably extracted through SOP Green Energy, a subsidiary of Sarawak Oil Palms in collaboration with the Malaysian Palm Oil Board (MPOB), ensuring responsible sourcing at every step.

◉ Research That Does Not Stop

AvantHealth is not just referencing old studies. The team continues to actively invest in new clinical research.

Through the EXPLORAT3 Clinical Seed Fund launched in January 2026, AvantHealth is funding pilot-scale clinical trials evaluating tocotrienol-based products across priority areas including brain health, liver health, skin health, and inflammatory conditions.

The programme runs from June 2026 to December 2027, with results expected to contribute to future publications and clinical applications.

As Featured In

What Tocotrienols Do For Your Brain

Thirty years of research. One consistent finding. Your brain deserves better protection.

Your brain consumes about 20% of your body's oxygen despite making up only a small percentage of your body weight. That makes brain cells especially vulnerable to oxidative stress over time.

As we age, the accumulation of free radical damage and inflammation in brain cells contributes to cognitive decline, memory loss, stroke and dementia.

Tocotrienols have been studied specifically for their role in protecting the brain at the cellular level.

— Here is what the research found —

🧬 Protects Brain White Matter

A clinical study published in the renowned journal, Stroke, reported that tocotrienols showed neuroprotective effects by slowing down the progression of brain white matter lesions in human subjects and reduced stroke lesion volume in animal models of ischemic stroke. A separate study confirmed alpha-tocotrienol as the most potent neuroprotective form of natural Vitamin E.

💡 Supports Memory and Cognitive Function

Research published in the Journal of Clinical Biochemistry and Nutrition found that tocotrienol improves learning and memory functions. Low tocopherol and tocotrienol levels were associated with increased risk of both mild cognitive impairment and Alzheimers’ Dementia. ⁷⁵

⚡ Supports Brain during Stroke

Alpha-tocotrienol is the most potent neuroprotective form of tocotrienols. Research published in the Journal of Ceberal Blood Flow and Metabolism found it effective in protecting the brain during ischemic stroke.

Source: Han-A Park et al. Natural Vitamin E α-Tocotrienol Protects Against Ischemic Stroke. Stroke | June 2011. https://pubmed.ncbi.nlm.nih.gov/21546471/

🧩 Helps Protect Against Vascular Dementia

Palm oil tocotrienol-rich fraction has been studied for its neuroprotective properties against vascular dementia — a serious global health concern that becomes more common with age and is closely linked to type 2 diabetes.

⁷⁵ Mangialasche F, Xu W, Kivipelto M, et al. Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. Neurobiol Aging. 2012;33(10):2282–2290. doi: 10.1016/j.neurobiolaging.2011.11.019

What This Means For You

Protecting your brain is not something you do after symptoms appear.

It is something you do long before — at the cellular level, every day. Avtriee® gives you that protection. Every softgel. Every day.

What Tocotrienols Do For Your Liver

Fatty liver often develops silently for years before symptoms become noticeable. By the time most people find out, the condition has already been progressing quietly — driven by obesity, insulin resistance, lipid peroxidation, and oxidative stress. The evidence on tocotrienols and liver health is some of the strongest in the research library.

— Here is what the studies show

🧪

Supports Healthy Liver Function in Fatty Liver Disease

A randomised placebo-controlled clinical trial led by Emeritus Professor Dr Yuen Kah Hay, found that tocotrienols supported the reduction of liver fat in patients with fatty liver. ² A 2023 systematic review published in Nutrients reviewed tocotrienols as a promising management strategy for NAFLD. NAFLD, now defined as metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most common liver disorders globally.

🔬

Tocotrienols Slowed the Progression of end-stage liver disease

A study published in the Journal of Nutrition found that oral tocotrienols are transported to human tissues and delayed the progression of end-stage liver disease.

⚗️

Helps Reduce Fat Accumulation in the Liver

Research published in the Journal of Clinical Biochemistry and Nutrition found that gamma-tocotrienol reduces fat accumulation in the liver through the regulation of fatty acid metabolism enzymes.

📋

Promising Strategy for Managing NAFLD

A 2023 systematic review published in Nutrients recommended tocotrienols as a promising management strategy for non-alcoholic fatty liver disease, now defined as metabolic dysfunction-associated steatotic liver disease.

👶

Shown to be Beneficial in Children with Fatty Liver

A study published in BMC Paediatrics found that tocotrienols reduced hepatic steatosis (liver fat), reduced DNA damage parameters and pro-inflammatory cytokine markers. ¹

¹ Al-Baiaty, F.D.R., Ishak, S., Mohd Zaki, F. et al. Assessing the efficacy of tocotrienol-rich fraction vitamin E in obese children with non-alcoholic fatty liver disease: a single-blind, randomized clinical trial. BMC Pediatr 24, 529 (2024). https://doi.org/10.1186/s12887-024-04993-8

² Magosso E, Ansari MA, Gopalan Y, Shuaib IL, Wong JW, Khan NA, Abu Bakar MR, Ng BH, Yuen KH. Tocotrienols for normalisation of hepatic echogenic response in nonalcoholic fatty liver: a randomised placebo-controlled clinical trial. Nutrition Journal. Dec 2013. https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-12-166

Start Protecting Your Liver

Don't wait for your next blood test to surprise you.

Liver protection at the cellular level — one softgel, every day. That is how tocotrienols work. That is what Avtriee® delivers.

Research That

Speaks For Itself.

Supported by over 30 clinical studies across 6 key areas of health, tocotrienols have been extensively researched for decades. Their health benefits are grounded in published scientific evidence and documented in peer-reviewed journals worldwide.

Below is a summary of the key research across six health categories.

🔥

Anti-Inflammatory Properties

Tocotrienols have been studied extensively for their ability to reduce inflammation — one of the key drivers of age-related health concerns.

Key finding: Palm oil tocotrienols exhibit anti-inflammatory characteristics comparable to or exceeding those of tocopherols — opening new opportunities to prevent or treat age-related chronic diseases.

⚡

Powerful Antioxidants

Tocotrienols act as chain-breaking antioxidants — neutralising harmful free radicals before they cause cellular damage.

Key finding: Tocotrienol-rich fraction of palm oil possesses potent antioxidant activities — suppressing the expression of inflammatory mediators in human cells.

🧠

Neuroprotection

Tocotrienols have been studied for their role in protecting brain cells against oxidative damage — with specific research in areas including stroke, dementia, and cognitive function.

Key finding: Alpha-tocotrienol is the most potent neuroprotective form of natural Vitamin E. A clinical study published in Stroke confirmed that mixed tocotrienols showed protective effects on brain white matter lesions in human subjects.

🫁

Liver Health

Tocotrienols have been investigated in human studies for their role in supporting healthy liver fat metabolism and helping maintain normal liver function.

Key finding: A randomised placebo-controlled clinical trial published in Nutrition Journal — co-authored by Emeritus Professor Dr Yuen Kah Hay — found that tocotrienols supported the normalisation of liver response in patients with nonalcoholic fatty liver disease. A 2023 systematic review published in Nutrients confirmed tocotrienols as a promising management strategy for NAFLD.

✨

Skin Health

Tocotrienols have been studied for their role in protecting skin against UV-induced damage and supporting healthy aging from within.

Key finding: Tocotrienol-rich fraction attenuates UV-induced inflammaging — protecting skin against the chronic low-grade inflammation caused by sun exposure. A 2022 systematic review published in Frontiers in Pharmacology confirmed the role of tocotrienols in supporting skin health as it ages.

❤️

Heart Health

Tocotrienols have been studied for their ability to support healthy cholesterol metabolism and cardiovascular health.

Key finding: Tocotrienol-enriched palm oil prevents atherosclerosis development. Tocotrienols also regulate cholesterol production at the cellular level — decreasing hepatic cholesterol production and reducing plasma cholesterol levels.

© Avantsar International Sdn Bhd (1478591-M)